Emergency Services are continuing to deal with a road traffic collision that occurred at 9:24 am this morning (19 April 2014) on the A66 near Threlkeld.
Two vehicles were involved, an Mercedes estate and a Ford Range pickup.
All casualties have been take to hospital, some by air ambulance.
The Mercedes estate did set on fire, however all occupants had been pulled from the vehicle prior to the fire starting.
The road will remain closed for the foreseeable future.
Diversions are in place, people travelling from Keswick are asked to travel along St Johns in the Vale. Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.