Police say a recovery operation took eight hours to complete after a lorry overturned near Messingham.
The incident happened at around 2.20pm yesterday (Friday), on the B1400 between Messingham and the Scotter turn-off.
Police closed the road while the vehicle was recovered, and it did not re-open until 10.30pm last night.
Yorkshire Air Ambulance was also at the scene, with two people in the lorry suffering what police described as non-life threatening injuries.
One man was believed to have been trapped in the cab of the lorry, but was cut free by firefighters who removed the windscreen and made a hole in the roof.
The man inside was then placed on a spinal board and moved through the gap.
After contacting North Lincolnshire Council, Humberside Police said that the lorry had been carrying a large quantity of clay – which spilled onto the carriageway when it overturned.
The road had to be cleared and jet-washed after the vehicle was recovered, to make it safe for other motorists